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matlab-based application lava  (MathWorks Inc)


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    MathWorks Inc matlab-based application lava
    Spatial-temporal analyses <t>of</t> <t>vascular-astrocyte</t> endfeet activity by <t>LAVA</t> application . A . Cartoon illustration showing analyses of astrocyte endfeet pairings within individual arteriole segments (blue lines) during airpuff-induced dilations (white arrows). B , Two photon micrograph of a cerebral penetrating arteriole (red) and summated activity map of astrocyte Ca 2+ signals (green). C , Modeling and sampling of arteriole crosssections are used to produce linearized channel clips containing the vessel of interest (white) and perivascular spaces (Ca 2+ activity in green). Vascular tone is measured from cross sectional area measurements, as well as close capture of astrocyte endfeet (1 and 2). D , Same FOV shown in panel B assessed during whisker stimulation. Endfoot ROIs (1 and 2 pink) and vascular mask (white) determined from the linearized vessel model (panel C) are mapped onto raw channels. E , Measurements of vascular tone from linearlized model in panel C and Ca2+ levels recorded from each endfoot (1 and 2) in panel D are plotted to display temporal associations of field activity. F-G , Pie charts showing the functional make-up of endfeet-arteriole pairings for WT ( F ) and 5xFAD ( G ) mice. Red indicates arteriole dilations with a subsequent endfoot Ca 2+ response; Blue indicates arteriole dilations in the absence of an endfoot response; Yellow indicates endfoot Ca 2+ response in the absence of an arteriole dilation; Black indicates pairings with neither an arteriole dilation, nor an endfoot Ca 2+ response. H , Scatter plots showing the endfoot Ca 2+ response latency ( i.e. latency between initial stimulation induced vasodilation and subsequent endfoot Ca 2+ signals). I , Scatterplot shows evoked Ca 2+ transient amplitudes in arteriole-associated endfeet. J , Scatterplots show the proportional relationship between Ca 2+ transient amplitude in each endfoot relative to vessel cross sectional area in the immediately adjacent arteriole. In H and J , each plot symbol represents an individual endfoot-arteriole pairing. In I , each plot symbol represents an individual mouse. p values derived from two-tailed T tests.
    Matlab Based Application Lava, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/matlab-based application lava/product/MathWorks Inc
    Average 90 stars, based on 1 article reviews
    matlab-based application lava - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "Loss of signaling fidelity between astrocyte endfeet and adjacent cerebral arterioles in an amyloid mouse model of Alzheimer’s disease"

    Article Title: Loss of signaling fidelity between astrocyte endfeet and adjacent cerebral arterioles in an amyloid mouse model of Alzheimer’s disease

    Journal: bioRxiv

    doi: 10.1101/2025.01.24.634584

    Spatial-temporal analyses of vascular-astrocyte endfeet activity by LAVA application . A . Cartoon illustration showing analyses of astrocyte endfeet pairings within individual arteriole segments (blue lines) during airpuff-induced dilations (white arrows). B , Two photon micrograph of a cerebral penetrating arteriole (red) and summated activity map of astrocyte Ca 2+ signals (green). C , Modeling and sampling of arteriole crosssections are used to produce linearized channel clips containing the vessel of interest (white) and perivascular spaces (Ca 2+ activity in green). Vascular tone is measured from cross sectional area measurements, as well as close capture of astrocyte endfeet (1 and 2). D , Same FOV shown in panel B assessed during whisker stimulation. Endfoot ROIs (1 and 2 pink) and vascular mask (white) determined from the linearized vessel model (panel C) are mapped onto raw channels. E , Measurements of vascular tone from linearlized model in panel C and Ca2+ levels recorded from each endfoot (1 and 2) in panel D are plotted to display temporal associations of field activity. F-G , Pie charts showing the functional make-up of endfeet-arteriole pairings for WT ( F ) and 5xFAD ( G ) mice. Red indicates arteriole dilations with a subsequent endfoot Ca 2+ response; Blue indicates arteriole dilations in the absence of an endfoot response; Yellow indicates endfoot Ca 2+ response in the absence of an arteriole dilation; Black indicates pairings with neither an arteriole dilation, nor an endfoot Ca 2+ response. H , Scatter plots showing the endfoot Ca 2+ response latency ( i.e. latency between initial stimulation induced vasodilation and subsequent endfoot Ca 2+ signals). I , Scatterplot shows evoked Ca 2+ transient amplitudes in arteriole-associated endfeet. J , Scatterplots show the proportional relationship between Ca 2+ transient amplitude in each endfoot relative to vessel cross sectional area in the immediately adjacent arteriole. In H and J , each plot symbol represents an individual endfoot-arteriole pairing. In I , each plot symbol represents an individual mouse. p values derived from two-tailed T tests.
    Figure Legend Snippet: Spatial-temporal analyses of vascular-astrocyte endfeet activity by LAVA application . A . Cartoon illustration showing analyses of astrocyte endfeet pairings within individual arteriole segments (blue lines) during airpuff-induced dilations (white arrows). B , Two photon micrograph of a cerebral penetrating arteriole (red) and summated activity map of astrocyte Ca 2+ signals (green). C , Modeling and sampling of arteriole crosssections are used to produce linearized channel clips containing the vessel of interest (white) and perivascular spaces (Ca 2+ activity in green). Vascular tone is measured from cross sectional area measurements, as well as close capture of astrocyte endfeet (1 and 2). D , Same FOV shown in panel B assessed during whisker stimulation. Endfoot ROIs (1 and 2 pink) and vascular mask (white) determined from the linearized vessel model (panel C) are mapped onto raw channels. E , Measurements of vascular tone from linearlized model in panel C and Ca2+ levels recorded from each endfoot (1 and 2) in panel D are plotted to display temporal associations of field activity. F-G , Pie charts showing the functional make-up of endfeet-arteriole pairings for WT ( F ) and 5xFAD ( G ) mice. Red indicates arteriole dilations with a subsequent endfoot Ca 2+ response; Blue indicates arteriole dilations in the absence of an endfoot response; Yellow indicates endfoot Ca 2+ response in the absence of an arteriole dilation; Black indicates pairings with neither an arteriole dilation, nor an endfoot Ca 2+ response. H , Scatter plots showing the endfoot Ca 2+ response latency ( i.e. latency between initial stimulation induced vasodilation and subsequent endfoot Ca 2+ signals). I , Scatterplot shows evoked Ca 2+ transient amplitudes in arteriole-associated endfeet. J , Scatterplots show the proportional relationship between Ca 2+ transient amplitude in each endfoot relative to vessel cross sectional area in the immediately adjacent arteriole. In H and J , each plot symbol represents an individual endfoot-arteriole pairing. In I , each plot symbol represents an individual mouse. p values derived from two-tailed T tests.

    Techniques Used: Activity Assay, Sampling, Whisker Assay, Functional Assay, Derivative Assay, Two Tailed Test



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    matlab-based application lava  (MathWorks Inc)
    90
    MathWorks Inc matlab-based application lava
    Spatial-temporal analyses <t>of</t> <t>vascular-astrocyte</t> endfeet activity by <t>LAVA</t> application . A . Cartoon illustration showing analyses of astrocyte endfeet pairings within individual arteriole segments (blue lines) during airpuff-induced dilations (white arrows). B , Two photon micrograph of a cerebral penetrating arteriole (red) and summated activity map of astrocyte Ca 2+ signals (green). C , Modeling and sampling of arteriole crosssections are used to produce linearized channel clips containing the vessel of interest (white) and perivascular spaces (Ca 2+ activity in green). Vascular tone is measured from cross sectional area measurements, as well as close capture of astrocyte endfeet (1 and 2). D , Same FOV shown in panel B assessed during whisker stimulation. Endfoot ROIs (1 and 2 pink) and vascular mask (white) determined from the linearized vessel model (panel C) are mapped onto raw channels. E , Measurements of vascular tone from linearlized model in panel C and Ca2+ levels recorded from each endfoot (1 and 2) in panel D are plotted to display temporal associations of field activity. F-G , Pie charts showing the functional make-up of endfeet-arteriole pairings for WT ( F ) and 5xFAD ( G ) mice. Red indicates arteriole dilations with a subsequent endfoot Ca 2+ response; Blue indicates arteriole dilations in the absence of an endfoot response; Yellow indicates endfoot Ca 2+ response in the absence of an arteriole dilation; Black indicates pairings with neither an arteriole dilation, nor an endfoot Ca 2+ response. H , Scatter plots showing the endfoot Ca 2+ response latency ( i.e. latency between initial stimulation induced vasodilation and subsequent endfoot Ca 2+ signals). I , Scatterplot shows evoked Ca 2+ transient amplitudes in arteriole-associated endfeet. J , Scatterplots show the proportional relationship between Ca 2+ transient amplitude in each endfoot relative to vessel cross sectional area in the immediately adjacent arteriole. In H and J , each plot symbol represents an individual endfoot-arteriole pairing. In I , each plot symbol represents an individual mouse. p values derived from two-tailed T tests.
    Matlab Based Application Lava, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/matlab-based application lava/product/MathWorks Inc
    Average 90 stars, based on 1 article reviews
    matlab-based application lava - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Spatial-temporal analyses of vascular-astrocyte endfeet activity by LAVA application . A . Cartoon illustration showing analyses of astrocyte endfeet pairings within individual arteriole segments (blue lines) during airpuff-induced dilations (white arrows). B , Two photon micrograph of a cerebral penetrating arteriole (red) and summated activity map of astrocyte Ca 2+ signals (green). C , Modeling and sampling of arteriole crosssections are used to produce linearized channel clips containing the vessel of interest (white) and perivascular spaces (Ca 2+ activity in green). Vascular tone is measured from cross sectional area measurements, as well as close capture of astrocyte endfeet (1 and 2). D , Same FOV shown in panel B assessed during whisker stimulation. Endfoot ROIs (1 and 2 pink) and vascular mask (white) determined from the linearized vessel model (panel C) are mapped onto raw channels. E , Measurements of vascular tone from linearlized model in panel C and Ca2+ levels recorded from each endfoot (1 and 2) in panel D are plotted to display temporal associations of field activity. F-G , Pie charts showing the functional make-up of endfeet-arteriole pairings for WT ( F ) and 5xFAD ( G ) mice. Red indicates arteriole dilations with a subsequent endfoot Ca 2+ response; Blue indicates arteriole dilations in the absence of an endfoot response; Yellow indicates endfoot Ca 2+ response in the absence of an arteriole dilation; Black indicates pairings with neither an arteriole dilation, nor an endfoot Ca 2+ response. H , Scatter plots showing the endfoot Ca 2+ response latency ( i.e. latency between initial stimulation induced vasodilation and subsequent endfoot Ca 2+ signals). I , Scatterplot shows evoked Ca 2+ transient amplitudes in arteriole-associated endfeet. J , Scatterplots show the proportional relationship between Ca 2+ transient amplitude in each endfoot relative to vessel cross sectional area in the immediately adjacent arteriole. In H and J , each plot symbol represents an individual endfoot-arteriole pairing. In I , each plot symbol represents an individual mouse. p values derived from two-tailed T tests.

    Journal: bioRxiv

    Article Title: Loss of signaling fidelity between astrocyte endfeet and adjacent cerebral arterioles in an amyloid mouse model of Alzheimer’s disease

    doi: 10.1101/2025.01.24.634584

    Figure Lengend Snippet: Spatial-temporal analyses of vascular-astrocyte endfeet activity by LAVA application . A . Cartoon illustration showing analyses of astrocyte endfeet pairings within individual arteriole segments (blue lines) during airpuff-induced dilations (white arrows). B , Two photon micrograph of a cerebral penetrating arteriole (red) and summated activity map of astrocyte Ca 2+ signals (green). C , Modeling and sampling of arteriole crosssections are used to produce linearized channel clips containing the vessel of interest (white) and perivascular spaces (Ca 2+ activity in green). Vascular tone is measured from cross sectional area measurements, as well as close capture of astrocyte endfeet (1 and 2). D , Same FOV shown in panel B assessed during whisker stimulation. Endfoot ROIs (1 and 2 pink) and vascular mask (white) determined from the linearized vessel model (panel C) are mapped onto raw channels. E , Measurements of vascular tone from linearlized model in panel C and Ca2+ levels recorded from each endfoot (1 and 2) in panel D are plotted to display temporal associations of field activity. F-G , Pie charts showing the functional make-up of endfeet-arteriole pairings for WT ( F ) and 5xFAD ( G ) mice. Red indicates arteriole dilations with a subsequent endfoot Ca 2+ response; Blue indicates arteriole dilations in the absence of an endfoot response; Yellow indicates endfoot Ca 2+ response in the absence of an arteriole dilation; Black indicates pairings with neither an arteriole dilation, nor an endfoot Ca 2+ response. H , Scatter plots showing the endfoot Ca 2+ response latency ( i.e. latency between initial stimulation induced vasodilation and subsequent endfoot Ca 2+ signals). I , Scatterplot shows evoked Ca 2+ transient amplitudes in arteriole-associated endfeet. J , Scatterplots show the proportional relationship between Ca 2+ transient amplitude in each endfoot relative to vessel cross sectional area in the immediately adjacent arteriole. In H and J , each plot symbol represents an individual endfoot-arteriole pairing. In I , each plot symbol represents an individual mouse. p values derived from two-tailed T tests.

    Article Snippet: In depth analyses of vascular motion and spatially paired astrocyte calcium signaling were characterized using our custom MATLAB-based application called LAVA.

    Techniques: Activity Assay, Sampling, Whisker Assay, Functional Assay, Derivative Assay, Two Tailed Test